FIGURE 1.

HIP/PAP (Reg3B) expression is elevated in human and mouse fibrotic lung tissues. Immunohistochemistry showed that type II alveolar epithelial cells were positively stained with anti‐HIP/PAP antibody in normal human lung tissues. HIP/PAP expression was drastically elevated in fibrotic human lung tissues, with the majority of the HIP/PAP‐positive signals found in seemingly hyperplastic alveolar epithelial cells (A). Expression of Reg3B in mouse lung tissues was upregulated at both the mRNA (B) and protein (C) levels from day 3 post‐BLM installation and increased steadily until day 28. Immunohistochemical staining showed that the expression patterns of Reg3B in normal and fibrotic mouse lung tissues are similar to those in the normal and fibrotic human lung tissues (D). Error bars indicate SD. Scale bars = 100 μm