FIGURE 3.

HIP/PAP increases SOD expression and activity in mouse lung tissue as well as cultured A549 and HLF‐1 cells. AdHIP/PAP alleviated the BLM‐induced decrease in SOD activity in mouse lung tissue (A). Moreover, AdHIP/PAP markedly increased SOD (Cu‐Zn SOD, Mn‐SOD and EC‐SOD) mRNA expression (B), resulting in an elevation of total SOD activity in otherwise normal mouse lung tissue (C). Likewise, rHIP/PAP (125 ng/mL) elevated Cu‐Zn SOD and Mn‐SOD mRNA expression in A549 (D) and HLF‐1 (E) cells, as well as total SOD activity in the cell lysates and culture medium (F, G). Error bars indicate SD