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. 2020 Apr 30;24(12):6804–6821. doi: 10.1111/jcmm.15334

FIGURE 4.

FIGURE 4

AdHIP/PAP alleviates BLM‐induced lung fibrosis in mice. The AdHIP/PAP‐mediated expression of HIP/PAP significantly attenuated BLM‐induced lung fibrogenesis in mice, as indicated by the decreased Col1A2 (A) and Col3A1 (B) mRNA expression, lower pulmonary hydroxyproline content (C), milder lung structure destruction, less picro‐sirius red‐positive collagen deposition (D) and, eventually, lower Ashcroft fibrosis score (E) compared with those of the NS + BLM and AdGFP + BLM groups. Moreover, overexpression of HIP/PAP lessened the BLM‐induced increases in pulmonary TGF‐β1; PDGF‐A, ‐B, and ‐C; CTGF; and PAI‐1 mRNA expression on both day 3 (F) and day 28 (G). # P < 0.05 vs the NS group, and * P < 0.05 vs the NS + BLM or AdGFP + BLM groups. Error bars indicate SD. Scale bars = 100 μm