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. 2020 Apr 30;24(12):6804–6821. doi: 10.1111/jcmm.15334

TABLE 3.

HIP/PAP antagonizes the TGF‐β1‐induced expression of pro‐fibrotic factors in HLF‐1 and A549 cells and HPMVEC (relative mRNA levels)

  Blank rHIP/PAP rhTGF‐β1 rhTGF‐β1 + rHIP/PAP
HFL‐1        
TGF‐β1 1.01 ± 0.05 0.95 ± 0.08 3.01 ± 0.31 # 1.83 ± 0.12*
CTGF 1.11 ± 0.10 1.09 ± 0.18 4.78 ± 0.13 # 1.27 ± 0.08*
PDGF‐A 1.01 ± 0.03 1.01 ± 0.05 3.58 ± 0.53 # 2.16 ± 0.29*
PDGF‐B 1.02 ± 0.03 0.97 ± 0.15 2.06 ± 0.20 # 1.52 ± 0.14*
PDGF‐C 1.01 ± 0.05 0.93 ± 0.09 2.50 ± 0.08 # 1.50 ± 0.14*
PAI‐1 1.01 ± 0.04 0.86 ± 0.15 7.31 ± 0.52 # 3.72 ± 0.27*
A549        
TGF‐β1 1.00 ± 0.09 1.07 ± 0.10 2.37 ± 0.31 # 1.56 ± 0.18*
CTGF 1.02 ± 0.03 1.11 ± 0.18 7.86 ± 0.18 # 4.23 ± 0.25*
PDGF‐A 1.01 ± 0.06 0.96 ± 0.34 9.31 ± 1.17 # 2.23 ± 0.29*
PDGF‐B 1.00 ± 0.04 1.16 ± 0.27 6.53 ± 0.78 # 3.60 ± 0.51*
PDGF‐C 1.02 ± 0.06 1.11 ± 0.13 4.21 ± 0.22 # 2.58 ± 0.16*
PAI‐1 1.02 ± 0.04 1.12 ± 0.16 11.05 ± 0.77 # 6.69 ± 0.49*
HPMVEC        
TGF‐β1 1.02 ± 0.02 0.58 ± 0.12 0.62 ± 0.18 0.67 ± 0.15
CTGF 1.01 ± 0.04 1.13 ± 0.09 3.21 ± 0.31 # 1.79 ± 0.19*
PDGF‐B 1.01 ± 0.02 0.97 ± 0.06 1.33 ± 0.08 # 0.81 ± 0.12*
PDGF‐C 1.03 ± 0.07 0.98 ± 0.05 1.12 ± 0.08 1.09 ± 0.18
PAI‐1 1.04 ± 0.06 1.09 ± 0.12 3.42 ± 0.17 # 3.02 ± 0.18
#

P < 0.01 vs the blank or rHIP/PAP groups, and

*

P < 0.01 vs the rhTGF‐β1 group.