TABLE 3.
Blank | rHIP/PAP | rhTGF‐β1 | rhTGF‐β1 + rHIP/PAP | |
---|---|---|---|---|
HFL‐1 | ||||
TGF‐β1 | 1.01 ± 0.05 | 0.95 ± 0.08 | 3.01 ± 0.31 # | 1.83 ± 0.12* |
CTGF | 1.11 ± 0.10 | 1.09 ± 0.18 | 4.78 ± 0.13 # | 1.27 ± 0.08* |
PDGF‐A | 1.01 ± 0.03 | 1.01 ± 0.05 | 3.58 ± 0.53 # | 2.16 ± 0.29* |
PDGF‐B | 1.02 ± 0.03 | 0.97 ± 0.15 | 2.06 ± 0.20 # | 1.52 ± 0.14* |
PDGF‐C | 1.01 ± 0.05 | 0.93 ± 0.09 | 2.50 ± 0.08 # | 1.50 ± 0.14* |
PAI‐1 | 1.01 ± 0.04 | 0.86 ± 0.15 | 7.31 ± 0.52 # | 3.72 ± 0.27* |
A549 | ||||
TGF‐β1 | 1.00 ± 0.09 | 1.07 ± 0.10 | 2.37 ± 0.31 # | 1.56 ± 0.18* |
CTGF | 1.02 ± 0.03 | 1.11 ± 0.18 | 7.86 ± 0.18 # | 4.23 ± 0.25* |
PDGF‐A | 1.01 ± 0.06 | 0.96 ± 0.34 | 9.31 ± 1.17 # | 2.23 ± 0.29* |
PDGF‐B | 1.00 ± 0.04 | 1.16 ± 0.27 | 6.53 ± 0.78 # | 3.60 ± 0.51* |
PDGF‐C | 1.02 ± 0.06 | 1.11 ± 0.13 | 4.21 ± 0.22 # | 2.58 ± 0.16* |
PAI‐1 | 1.02 ± 0.04 | 1.12 ± 0.16 | 11.05 ± 0.77 # | 6.69 ± 0.49* |
HPMVEC | ||||
TGF‐β1 | 1.02 ± 0.02 | 0.58 ± 0.12 | 0.62 ± 0.18 | 0.67 ± 0.15 |
CTGF | 1.01 ± 0.04 | 1.13 ± 0.09 | 3.21 ± 0.31 # | 1.79 ± 0.19* |
PDGF‐B | 1.01 ± 0.02 | 0.97 ± 0.06 | 1.33 ± 0.08 # | 0.81 ± 0.12* |
PDGF‐C | 1.03 ± 0.07 | 0.98 ± 0.05 | 1.12 ± 0.08 | 1.09 ± 0.18 |
PAI‐1 | 1.04 ± 0.06 | 1.09 ± 0.12 | 3.42 ± 0.17 # | 3.02 ± 0.18 |
P < 0.01 vs the blank or rHIP/PAP groups, and
P < 0.01 vs the rhTGF‐β1 group.