Figure 9.

Schematic illustrating the possible mechanisms of protective effect of Sal B against ototoxic drug–induced apoptosis. As illustrated, neomycin or cisplatin treatment markedly induces the production of ROS and triggers mitochondrial apoptotic pathway. Sal B treatment could reduce the generation of ROS; decrease the expression levels of apoptosis proteins; increase the expression levels of anti‐apoptotic proteins; induce the activation of anti‐apoptotic PI3K/AKT pathway; and eventually ameliorate the oxidative stress–induced apoptosis