Figure 1.
The sumoylation of C/EBPα and its relationship with pulmonary surfactant protein expression in BPD rat. Three neonatal rats per group were selected were killed from newborn rats at P7 and P14 and one sample repeated three times in our experiment; normoxia group: 21% O2, hyperoxia group: 80%‐85% O2. The protein expression of SUMO1, C/EBPα and pulmonary surfactant proteins (SPs, including SP‐A, SP‐B, SP‐C and SP‐D) was detected by Western blot assays in the four groups. β‐Actin was used as the loading control (A and C). Co‐immunoprecipitation (Co‐IP); the levels of sumoylated C/EBPα were significantly increased during hyperoxia conditions (B). Values represent mean ± SD; ** P < .05 vs normoxia group