Table 1. Altered Fucosyltransferase Expression in Response to β-catenin/CBP Inhibition.

Expression change of fucosyltransferases FUT2, FUT3, FUT8, the epidermal growth factor receptor (EGFR), and E-cadherin (CDH1) after treatment with ICG-001 (top) or E7386 (bottom) compared to vehicle control (DMSO) in indolent CAL27 and metastatic HSC-3 cells. The fold change of the treatment compared to the DMSO control (Fold Δ) and q-value (q, FDR adjusted) are shown for each condition tested.

	ICG-001 v Vehicle
	HSC-3		CAL27
	Fold Δ	q	Fold Δ	q
FUT2	+2.1	2.0 × 10−5	+1.1	5.4 × 10−1
FUT3	+3.0	5.7 × 10−8	+1.4	1.5 × 10−1
FUT8	+1.2	9.0 × 10−3	+1.2	1.2 × 10−1
EGFR	+1.1	3.9 × 10−1	+1.3	2.1 × 10−2
CDH1	+1.2	5.1 × 10−2	−1.1	3.6 × 10−1
	E7386 v Vehicle
	HSC-3		CAL27
	Fold Δ	q	Fold Δ	q
FUT2	+2.4	1.4 × 10−3	NC	-
FUT3	+2.3	5.5 × 10−4	+1.6	1.8 × 10−2
FUT8	+1.4	5.0 × 10−3	+1.1	2.6 × 10−1
EGFR	+1.5	3.3 × 10−3	+1.5	1.3 × 10−2
CDH1	+1.2	8.1 × 10−2	−1.1	6.3 × 10−1