Table 5:

Multivariate^* PCS and MCS Models for Categories for Medical and Mental Comorbidities

Variable	Adjusted Model 3: Most Parsimonious PCS Model&				Adjusted Model 4: Most Parsimonious MCS Model$
	β	SE	95%CI	P-Value	β	SE	95%CI	P-Value
Medical Comorbidity Categories  Diabetes  MI and CV Diseases  Cancers  Other chronic medical Disorders  No Chronic Medical Disorder	−3.44 −10.59 −3.19 −0.84 Ref.	1.17 2.25 1.19 2.10 Ref.	−5.74 – − 1.15 −15.01 – −6.18 −5.52 – − 0.86 −4.97 – 3.28 Ref.	0.003 <.0001 0.007 0.69 Ref.
Medical Comorbidity Categories*Time   Diabetes*Time   MI and CV Diseases*Time   Cancers*Time   Other chronic medical Disorders*Time   No Chronic Medical Disorder*Time	0.65 2.10 0.55 0.32 Ref.	0.31 0.58 0.32 0.55 Ref.	0.04 – 1.25 0.96 – 3.25 −0.07 – 1.18 −0.76 – 1.40 Ref.	0.04 0.0003 0.08 0.56 Ref
Mental Comorbidity Categories   Major Depressive Disorder   Anxiety/Bipolar Disorder   Alcohol Abuse   Other Mental Comorbidities   No Mental Comorbidity	−3.17 −3.81 −3.14 −2.99 Ref.	0.55 0.83 1.04 1.05 Ref.	−4.25 – 2.09 −5.44 – 2.17 −5.19 – 1.10 −5.05 – − 0.93 Ref.	<.0001 <.0001 0.003 0.005 Ref.	−4.98 −4.93 −3.40 −2.84 Ref.	0.55 0.84 1.05 1.05 Ref.	−6.07 – 3.90 −6.58 – 3.28 −5.46 – 1.35 −4.91 – − 0.78 Ref.	<.0001 <.0001 0.001 0.007 Ref.
Time (One-Yearly Increment)	−0.76	0.29	−1.33 – − 0.20	0.008	0.10	0.08	−0.07 – 0.27	0.24
Intercept	61.50	1.89	57.78 – 65.22	<.0001	44.91	1.79	41.40 – 48.42	<.0001

^*Gray= p>0.2 in univariate analysis, so not included in model (see Tables 2 and 3);

^&Controlled for same set of covariates as in Table 4, Model 1;

^$Controlled for same set of covariates as in Table 4, Model 2

PCS: physical component summary scores; MCS: mental component summary scores; HAART: highly active antiretroviral therapy; PI-HAART: protease inhibitor-based HAART; NPI-HAART: non-protease inhibitor-based HAART; HAART-naïve: never received HAART; Off-HAART: received HAART in the past but not currently on HAART; β: beta; SE: standard error; 95%CI: 95% confidence interval