Table 3.
Treatment groups for studying in vivo release profile of insulin.
Group number | Treatment | Insulin dose (IU/kg) | Frequency of administration |
---|---|---|---|
I | Healthy control | - | - |
II | Diabetic control | - | - |
III | Free insulin solution | 0.5 IU/kg | Single |
IV | Glargine | 0.5 IU/kg/day | Repeated every 24 h |
V | Free insulin in thermosensitive copolymer solution | 45 IU/kg | Single |
VI | CSO-Zinc insulin complexes in thermosensitive copolymer solution | 45 IU/kg | Single |
VII | Oleic acid-g-CSO zinc insulin complexes in thermosensitive copolymer solution | 45 IU/kg | Single |