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. Author manuscript; available in PMC: 2021 Jul 10.
Published in final edited form as: J Control Release. 2020 Apr 10;323:161–178. doi: 10.1016/j.jconrel.2020.04.012

Table 3.

Treatment groups for studying in vivo release profile of insulin.

Group number Treatment Insulin dose (IU/kg) Frequency of administration
I Healthy control - -
II Diabetic control - -
III Free insulin solution 0.5 IU/kg Single
IV Glargine 0.5 IU/kg/day Repeated every 24 h
V Free insulin in thermosensitive copolymer solution 45 IU/kg Single
VI CSO-Zinc insulin complexes in thermosensitive copolymer solution 45 IU/kg Single
VII Oleic acid-g-CSO zinc insulin complexes in thermosensitive copolymer solution 45 IU/kg Single