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Ice slurry is safe and selective for targeting the sciatic nerve. (A) Temperature recording shows rapid decrease in the compartment around the sciatic nerve followed by gradual warming. (B) Representative images of skin (upper panels), and muscle tissue (lower panels) at the injection site stained with H&E at 7 days post ice slurry injection; scale bar: 25 μm. There is no evidence of injury to skin or muscle.
