Skip to main content
. 2020 Apr 19;39(25):4781–4797. doi: 10.1038/s41388-020-1284-6

Fig. 1. Generation and characterisation of palbociclib resistance models.

Fig. 1

a Antiproliferative effect of palbociclib in several palbociclib-resistant (PalboR, blue lines) and -sensitive (PalboS, black lines) cell lines. For washout experiments, palbociclib was omitted from the growth medium for a period of 2 weeks (short, red line) and 4 weeks (long, green line) and then re-challenged with escalating concentrations of palbociclib (n = 3 biological and n = 8 technical replicates). Data represents % viable cells compared with vehicle control for each cell line. Error bars represent mean ± SEM. b Copy number variation comparing palbociclib resistance versus sensitivity in MCF7, MCF7 LTED, T47D, T47D LTED and HCC1428 LTED cell lines. c Identification of pathways and genes associated with resistance to palbociclib in MCF7, MCF7 LTED and T47D cell models (n = 3 biological replicates).