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. 2020 Apr 19;39(25):4781–4797. doi: 10.1038/s41388-020-1284-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Abundance of ER and cell cycle markers in palbociclib-sensitive and -resistant in MCF7, MCF7 LTED, T47D, T47D LTED and HCC1428 LTED cell lines (n = 3 biological replicates). b Schematic representation of phosphorylation networks using Photon comparing parent and palbociclib-resistant (PalboR) derivatives followed by identification of pathways associated with resistance using PhosphoPath (n = 3 biological replicates). RB1 marked with red circle.