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. 2020 Apr 19;39(25):4781–4797. doi: 10.1038/s41388-020-1284-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Long-term study assessing changes in relative tumour volumes over 60 days of treatment with palbociclib alone (50 mg/kg) or in combination with everomilus (2.5 mg/kg), neratinib (40 mg/kg) and AZD1775 (90 mg/kg) in the presence or absence of fulvestrant (50 mg/kg) in a PDX model of resistant to palbociclib (HBCx-134 palbo-R31). Statistical significance was calculated using unpaired t-test. Data was available for four to seven animals per group. *p < 0.05; **p < 0.01; ***p < 0.001. Error bars represent means ± SEM.