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. 2020 Jun 17;11:3077. doi: 10.1038/s41467-020-16682-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — The illustration on the top shows the locations of tumors selected for this study. Numbers in the parentheses indicated case counts in the code index respectively. Based on methylation patterns, brainstem gliomas could be differentiated into four subtypes: H3-Pons, H3-Medulla, IDH, and PA-like. Clinical information was listed in columns. Tumor location, histopathology, grade, and diagnosis of DIPG are showed in frequency as barplots. Survival data was showed as Kaplan–Meier curves, and age at diagnosis is represented as density plot. Several hallmark mutations are selected and showed in frequency as barplots.