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. 2020 Jun 17;10:9869. doi: 10.1038/s41598-020-66693-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Comparison of average transit time of control and SCD RBCs. For SCD RBCs, the transit time is more dispersed with a longer transit time for a part of the cell population; (B) Comparison of average blockade amplitude of control and SCD RBCs. Three main populations are observed when examining the blockade amplitude (Supplementary Table S3). The transit time resolution is 0.8 ms and the blockade amplitude resolution is 8 × 10⁻⁵ V. On these graphs data was collected from 1696 control RBCs coming from 6 healthy donors, and 1298 SCD RBCs coming from 5 patients. Images a, b and c (graph B) correspond to subpopulations of SCD RBCs, while image d corresponds to control RBCs.