Table 1.
Clinical characteristics and outcome data.
| Characteristic | Epstein-Barr virus-negative (n = 459) | Epstein-Barr virus-positive (n = 271) | p-value |
|---|---|---|---|
| Age (years) | 60.5 (17–92) | 62.4 (19–91) | 0.11 |
| Male sex^ | 275 (60%) | 141 (52%) | 0.049 |
| Charlson comorbidity index* | 2.8 (0–10) | 2.6 (0–9) | 0.30 |
| ICU-acquired infection^ | 87 (19%) | 66 (24%) | 0.098 |
| Mortality (28-day)§ | 72 (16%) | 64 (24%) | 0.051 |
| Intensive care unit length of stay§ (days) | 9.2 (1–101) | 12.9 (1–55) | 0.0040 |
| Sequential Organ Failure Assessment score (day 1)* | 5.9 (0–17) | 6.9 (1–19) | 0.00011 |
| Sequential Organ Failure Assessment score (maximum over the first 7 days of admission)* | 6.7 (0–19) | 7.9 (1–21) | 3.6 × 10−6 |
Epstein-Barr virus-negative and Epstein-Barr virus-positive individuals are compared (total n = 730). Intensive care unit length of stay analysis only includes patients surviving to intensive care unit discharge. T-test performed except where indicated (^Chi-squared test; *Mann-Whitney U-test; §Log-rank test). Summary values refer to the mean. The range of values observed is provided where relevant.