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. 2020 Jun 17;10:9805. doi: 10.1038/s41598-020-66902-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Global proteotype associated with high PD-L1 abundance in 26 sample NSCLC subcohort. (A) Highest abundance proteins in NSCLC global analyses as a function of PD-L1 MS protein level. (B) Significantly enriched Hallmark 50 pathways associated with PD-L1 MS protein level by GSEA. (C) Enrichment plot for Myc targets (variant 1) depicting enrichment score (upper panel) versus ranked abundance (lower panel) for all pathway proteins (depicted as tick marks) quantified in the global dataset.