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. 2020 Jun 17;11:3070. doi: 10.1038/s41467-020-16876-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Overall structures of HKU2 and SADS-CoV spike glycoproteins shown in side view (upper panel) and top view (lower panel). Three monomers of HKU2 spike are colored magenta, green, and orange, respectively; three monomers of SADS-CoV spike are colored pink, yellow, and cyan, respectively. The cryo-EM maps are shown as semitransparent surface and contoured at 2.6 RMS and 3 RMS for HKU2 and SADS-CoV spikes, respectively. The trigonal axes are shown as black dashed lines. Visible segments of each monomer are labeled accordingly. The cap, stalk, and root parts are partitioned by gray dashed lines. b Segmentation of HKU2 monomer. The segments of HKU2 are shown as boxes with the width related to the length of amino acid sequence. The start and end amino acids of each segment are labeled. The position of S1/S2, and S2′ cleavage sites are indicated. NTD N-terminal domain, CTD C-terminal domain, SD1 subdomain 1, SD2 subdomain 2, UH upstream helix, FP fusion peptide, CR connecting region, HR1 heptad repeat 1, CH central helix, BH β-hairpin, SD3 subdomain 3. c Overall structure of HKU2 monomer. Side views of HKU2 monomer shown in three directions. The segments are colored the same as in b.