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. 2020 Jun 17;11:3070. doi: 10.1038/s41467-020-16876-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Comparison of SD1 from four genera of coronaviruses. HKU2 SD1 is colored salmon; SD1 from other coronaviruses are colored gray. Disulfide bonds are shown as red sticks. Red arrows indicate the disulfide bonds conserved in all genera of coronaviruses. PDB codes: HCoV-NL63, 5SZS; MHV, 3JCL; IBV, 6CV0; PdCoV, 6B7N. b Comparison of SD2 from four genera of coronaviruses. HKU2 SD2 is colored salmon; SD2 from other coronaviruses are colored gray. Disulfide bonds are shown as red sticks. Red arrows indicate the disulfide bonds conserved in all genera of coronaviruses. Blue arrows indicate the disulfide bonds only found in HKU2 (and SADS-CoV) and β-CoVs. The additional helices of SD2 from HKU2 (and SADS-CoV) and βCoVs are colored yellow and partitioned by gray dashed lines. PDB codes: HCoV-NL63, 5SZS; MHV, 3JCL; IBV, 6CV0; PdCoV, 6B7N.