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. 2020 Jun 17;10:9800. doi: 10.1038/s41598-020-66704-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Principal components analysis of the species composition of in vitro oral biofilms obtained from healthy (a) and periodontal (b) saliva samples with and without the QQ enzyme Aii20J. Biofilms were cultured in BHI or BHI supplemented with 0.1% sucrose under aerobic and in BHI during 24 h and 48 h under anaerobic conditions. Closed symbols represent the control biofilms while open symbols represent the biofilms treated with the QQ enzyme Aii20J. Squares = BHI aerobic conditions, circles = BHI anaerobic conditions, triangles = BHI supplemented with 0.1% sucrose in aerobic conditions and diamonds = 48 h BHI in anaerobic conditions in both panels.