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. 2020 Jun 17;10:9832. doi: 10.1038/s41598-020-66785-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Tumor construct morphology and growth in vitro and in vivo. Tumor spheroid morphology was visualized on days 7 and 28 in vitro (a) and in vivo (b) in both collagen-only constructs and LX2 co-cultures, as indicated. Integration of vasculature was also observed at day 28 of in vivo implanted samples (insets f–i). Spheroid diameter was tracked over time in vitro (c), and in vivo implanted samples were measured at the time of explantation for average diameter (d). Examples of gross implant size in vivo can be seen in insets j, k. Implant retrieval data for the in vivo studies (e). Graphs represent mean + s.e.m. of experiments performed in triplicate.