Table 2.
The comparison of clinical characteristics between cerebellopontine angle WNT- and SHH-medulloblastomas.
| Characteristics | WNT (n = 5) No. of patients (%) | SHH (n = 10) No. of patients (%) | P* |
|---|---|---|---|
| Sex | |||
| Female | 1 (20) | 6 (60) | 0.282 |
| Male | 4 (80) | 4 (40) | |
| Age at diagnosis | |||
| <18 | 1 (20) | 2 (20) | 1.000 |
| ≥18 | 4 (80) | 8 (80) | |
| Origin# | |||
| Cerebellum | 0 (0) | 9 (90) | 0.002 |
| Brainstem | 5 (100) | 1 (10) | |
| Growth pattern | |||
| ICB/ICB + ECB | 1 (20) | 10 (100) | 0.004 |
| Only ECB | 4 (80) | 0 (0) | |
| 4th ventricle floor involvement | |||
| Yes | 3 (60) | 1 (10) | 0.077 |
| No | 2 (40) | 9 (90) | |
| CN involvement | |||
| Yes | 2 (40) | 5 (50) | 0.573 |
| No | 3 (60) | 5 (50) | |
| Cystic | |||
| Yes | 3 (20) | 6 (60) | 1.000 |
| No | 2 (80) | 4 (40) | |
| Enhancement | |||
| Solid | 5 (100) | 3 (30) | 0.026 |
| Heterogeneous or minimal | 0 (0) | 7 (70) | |
| Margin | |||
| Well-defined | 4 (80) | 4 (40) | 0.282 |
| Ill-defined | 1 (20) | 6 (60) | |
| Hemorrhage/mineralization | |||
| Yes | 1 (20) | 4 (40) | 0.600 |
| No | 4 (80) | 6 (60) | |
| Necrosis | |||
| Yes | 1 (20) | 7 (70) | 0.119 |
| No | 4 (80) | 3 (30) | |
| Histology | |||
| CMB | 5 (100) | 7 (70) | 0.505 |
| DNMB | 0 (0) | 3 (30) | |
Abbreviations: CMB, classic medulloblastoma; DNMB, desmoplastic/nodular medulloblastoma; ECB, extracerebellar; GTR, gross total resection; ICB, intracerebellar; CN, cranial nerve; STR, subtotal resection.
*Fisher’s exact test (2-sided). #The putative point of origin of the tumor is identified based on the pre- and postoperative MRI results and intraoperative reports.