Table 3.
Mean values of IgM/IgG binding and CDC among primates against 3 kinds of pig PBMCs.
| WT PBMCs | GTKO PBMCs | TKO PBMCs | |||||||
|---|---|---|---|---|---|---|---|---|---|
| IgM(rGM) | IgG(rGM) | CDC(%) | IgM(rGM) | IgG(rGM) | CDC(%) | IgM(rGM) | IgG(rGM) | CDC(%) | |
| Human (n = 9) | 31.8 | 9.3 | 85.7 | 19.5 | 5.7 | 66.7 | 3.4 | 1.2 | 2.7 |
| Baboon (n = 6) | 20.0 | 2.2** | 91.8 | 5.1** | 1.2** | 64.4 | 6.3 | 1.2 | 53.5** |
| Rhesus monkey (n = 6) | 18.9 | 4.7 | 92.6 | 9.3 | 1.2* | 68.5 | 10.5** | 1.1 | 91.8** |
| Cynomolgus monkey (n = 6) | 19.2 | 2.6** | 96.3 | 8.9 | 1.4 | 69.1 | 9.8** | 1.3 | 90.0** |
| African green monkey (n = 6) | 38.0 | 6.2 | 93.6 | 3.0** | 1.1** | 25.6** | 5.7 | 1.1 | 77.2** |
| Capuchin monkey (n = 9) | 5.7** | 2.0** | 49.2 | 8.1 | 2.6 | 72.7 | 2.4 | 0.9** | 15.0 |
| Squirrel monkey (n = 6) | 3.3** | 1.0** | 62.0 | 4.7** | 1.1** | 60.0 | 1.6* | 0.9 | 25.7 |
CDC = complement-dependent cytotoxicity; GTKO = α1,3-galactosyltransfearse gene-knockout; PBMC = peripheral blood mononuclear cell; rGM = relative geometric mean; TKO = triple -knockout; WT = wild type. (**p < 0.01, *p < 0.05, compared to humans).