Figure 4.

CCL8 Promotes Tumor Growth by Recruiting M2 Macrophages

(A) Representative images (20x) of mammary glands stained for Arginase I from SCID (wt) and Ccl8KOSCID (Ccl8KO) mice implanted with MCF10.DCIS.com (1x10⁶ cells) enclosed in Matrigel at day 2 of forced involution that followed 10 days of lactation (n = 5). Animals were sacrificed 2 days later. Scale bar, 10 μm.

(B) Quantification of cells per optic field positive for Arginase I of the results described above. Results are shown as average + SEM (∗, p < 0.05, Student's t test).