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. 2020 Jun 11;8:423. doi: 10.3389/fcell.2020.00423

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Copyright © 2020 Zilocchi, Colugnat, Lualdi, Meduri, Marini, Corasolla Carregari, Moutaoufik, Phanse, Pieroni, Babu, Garavaglia, Fasano and Alberio.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Rab7A was recruited to mitochondria in PARK2 patients. (A) Representative images of ATP synthase β (mitochondrial area) and Rab7A (quantification) signals from one control subject (C4) and one PARK2-mutated patient (P2) after DMSO or CCCP treatment. The merge panel shows the juxtaposition of the two signals. Insets show the magnification (165%) of details in squares. (B) Quantification of Rab7A signal per mitochondrial surface unit. Data were expressed as mean ± SEM. Statistical analysis was performed by two-way ANOVA, to assess the effect of “mutation” (control subjects vs. PARK2 patients), “treatment” (DMSO vs. CCCP), and “interaction.” “Treatment” (p = 0.74; F = 0.12) and “interaction” (p = 0.74; F = 0.11) did not result to be significant sources of variation. “Mutation” (p = 0.04; F = 5.97) resulted to be a significant source of variation.