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. 2020 Jun 11;8:423. doi: 10.3389/fcell.2020.00423

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Copyright © 2020 Zilocchi, Colugnat, Lualdi, Meduri, Marini, Corasolla Carregari, Moutaoufik, Phanse, Pieroni, Babu, Garavaglia, Fasano and Alberio.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Molecular pathways altered in the whole cell proteome of PARK2-mutated patients. The PPI network includes 100 nodes. (A) Yellow nodes, up-regulated proteins in PARK2-mutated patients; blue nodes, down-regulated in PARK2-mutated patients. (B) Over-represented pathways mapped on the PPI network. Pink nodes, microtubule-based movement; green nodes, translation; red nodes, signal transmission and transduction; purple nodes, glucose and hexose catabolic pathway.