Table 3.
Comparison between boys with and without hypogonadotropic hypogonadism (HH) in PSIS.
| With HH (n = 6) | Without HH (n = 15) | p | |
|---|---|---|---|
| Age at diagnosis, years | 2.0 ± 1.9 | 4.8 ± 2.3 | 0.01 |
| Age at last evaluation, years | 18.9 ± 7.2 | 16.7 ± 1.9 | 0.79 |
| Micropenis, n (%) | 3 (50) | 2 (13) | 0.12 |
| Cryptorchidism n/total (%) | 3/6 (50) | 1/14 (7) | 0.06 |
| Anterior pituitary height, mm | 1.4 ± 1.0 | 2.4 ± 1.5 | 0.27 |
| GH peak, mU/L | 6.8 ± 4.7 | 4.7 ± 3.7 | 0.24 |
| IGF1, nmol/L | 1.6 ± 1.4 | 3.7 ± 1.9 | 0.03 |
| Cortisol, nmol/L | 61.0 ± 57.7 | 393.9 ± 304.8 | <0.01 |
| Free thyroxin, pmol/L | 7.8 ± 2.3 | 14.8 ± 4.7 | <0.01 |
| Age at GnRH testing, years | 13.6 ± 1.2 | 13.7 ± 4.5 | 0.61 |
| LH peak, IU/L | 1.4 ± 1.5 | 15.0 ± 10.6 | <0.01 |
| FSH peak, IU/L | 2.8 ± 3.1 | 8.3 ± 8.9 | 0.06 |
| Testosterone, nmol/L | 0.1 ± 0.1 | 13.9 ± 9.7 | <0.01 |
| TV, mL | 3.8 ± 3.0 | 14.3 ± 1.5 | <0.01 |
| Age at inhibin B, years | 6.1 ± 5.0 | 7.6 ± 4.8 | 0.27 |
| Inhibin B, ng/L | 90.6 ± 108.7 | 148.7 ± 95.1 | 0.16 |
| Underrange inhibin B, n (%) | 3 (50) | 0 (0) | 0.02 |
Mean ± SD, TV, testicular volume. Conversion factors to SI units: IGF1 1 ng/mL = 0.13 nmol/L; cortisol 1 ng/mL = 2.76 nmol/L; testosterone 1 ng/mL = 3.47 nmol/L; inhibin B 1 pg/mL = 1 ng/L.
Bold values are statistically significant p-value.