Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jun 11;14:644. doi: 10.3389/fnins.2020.00644

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Iacomino, Baldassari, Tochigi, Kośla, Buffelli, Torella, Severino, Paladini, Mandarà, Riva, Scala, Balagura, Accogli, Nigro, Minetti, Fulcheri, Zara, Bednarek, Striano, Suzuki and Salpietro.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Cortical layer formation and neural migration in lde/lde rat brain compared to normal one. (A–D) Sagittal brain sections at P1 rats were subjected to Nissl staining. Squares as labeled C and D in panels (A,B) indicated identical areas as shown in panels (C,D), respectively. Arrowheads indicate delayed foliation in lde/lde cerebellum. (E) The thicknesses of cerebral wall (MZ to VZ/SVZ) is shown as mean ± S.D. from three independent experiments. Student’s t-test is used to determine statistical significance (^∗p < 0.05). (F) Sections are co-immunostained with anti-Satb2 (green) anti-Tbr1 (red). (I) Distribution of migrating neuronal cells labeled with BrdU (green) in cerebral cortex. Nuclei are counterstained with DAPI (blue). Representative images from three independent experiments are shown. The cell densities of Satb2 (G), Tbr1 (H), and BrdU-positive cells (J) in each area are plotted as histograms. Values are shown as the mean ± SD. The asterisk indicates a significant difference between +/+ and lde/lde in the same area by Student’s t-test (^∗p < 0.05, ^∗∗p < 0.01). Experimental scheme to label migrating cells by BrdU is illustrated in panel (J). MZ, marginal zone; IZ, intermediate zone; VZ, ventricular zone: SVZ, subventricular zone.