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. 2020 Jun 11;10:865. doi: 10.3389/fonc.2020.00865

Figure 5.

Figure 5

UCHL5 activated Wnt/β-catenin signaling and affected the expression of its target genes. (A) Relative protein levels of UCHL5 and β-catenin were detected by WB in HCE-1-A cells at 48 h after shRNA lentiviral infection (N = 3 times). *P < 0.05 vs. sh-NC. (B) Relative levels of cell cycle–related protein CyclinD1 and cell proliferation-related protein C-myc. (N = 3 times). *P < 0.05 vs. sh-NC. (C) Relative levels of cell apoptosis-related protein cleaved-caspase3 and anti-apoptosis protein Survivin (N = 3 times). *P < 0.05 vs. sh-NC. (D) Relative protein levels of UCHL5 and β-catenin were detected by WB in AN3-CA cells at 48 h after infected with overexpressed lentiviral vectors (N = 3 times). *P < 0.05 vs. empty vector. (E) Relative levels of CyclinD1 and C-myc (N = 3 times). *P < 0.05 vs. empty vector. (F) Relative levels of cleaved-caspase3 and Survivin (N = 3 times). *P < 0.05 vs. empty vector.