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. 2020 Jun 11;10:865. doi: 10.3389/fonc.2020.00865

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Copyright © 2020 Liu, Song, Wang and Ouyang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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UCHL5 silence restricted tumor growth via inhibiting Wnt/β-catenin signaling pathway in vivo. (A) Images of HCE-1-A tumor-bearing nude mice and isolated primary xenograft tumors (n = 6). (B) The growth curves of HCE-1-A primary xenograft tumors (n = 6). *P < 0.05 vs. sh-NC. (C) The weight of xenograft tumors (n = 6). *P < 0.05 vs. sh-NC. (D) Hematoxylin and eosin (HE) staining of tumors (n = 6). (E) Western blot detected the expression of UCHL5 and β-catenin (N = 3 times). *P < 0.05 vs. sh-NC. (F,G) Representative bands of CyclinD1, C-myc, cleaved-caspase3, Survivin, and GAPDH and their cartogram evaluated by western blot (N = 3 times). *P < 0.05 vs. sh-NC.