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. 2020 Jun 11;11:614. doi: 10.3389/fphar.2020.00614

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Copyright © 2020 Wang, Wang, Lu, Yan, Leng, Tian, Zheng, Wang and Bai

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effect of metformin on APD and I_Ca-L in cardiomyocytes isolated from diabetic mice. (A) Representative action potential traces in the Ctrl group, DM group, and the metformin-treatment group. (B) Relative levels of APD₉₀ in the Ctrl group, DM group, and the metformin-treatment group. (C) Relative levels of APD₅₀ with metformin in the Ctrl group, DM group, and the metformin-treatment group. (D) Representative I_Ca-L traces in the Ctrl group, DM group, and the metformin-treatment group. The holding potential was -40mV. (E) I-V curves of I_Ca-L in the Ctrl group, DM group, and the metformin-treatment group. Values represent mean ± SEM, n_Ctrl = n_DM = n_Metformin = 6. *P < 0.05 versus Ctrl, ^#P < 0.05 versus DM.