Figure 4.
The effect of metformin on APD and ICa-L in high glucose cultured primary neonatal mice cardiomyocytes. (A) Representative action potential traces of primary cardiomyocytes in NC group, HG group and metformin-treatment group. (B) Relative levels of APD90 of primary cardiomyocytes in NC group, HG group and metformin-treatment group. (C) Relative levels of APD50 of primary cardiomyocytes in NC group, HG group and metformin-treatment group. (D) Representative ICa-L traces of primary cardiomyocytes in NC group, HG group and metformin-treatment group. The holding potential was -40mV. (E) I-V curves of ICa-L, of primary cardiomyocytes in NC group, HG group and metformin-treatment group. Values represent mean ± SEM, nNC = nHG = nMetformin = 6. *P < 0.05 versus NC, #P < 0.05 versus HG.