Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
R-Ras is the master regulator of vascular permeability. Schematic presentation on the role of R-Ras in regulating vascular permeability. (A) Angiogenic blood vessels in retinopathy are hyperpermeable and leak. (B) R-Ras deficiency leads to reduced pericyte and VE-cadherin coverage on endothelial cells, and thus enhanced plasma leakage. (C) Increasing R-Ras expression normalizes pathological blood vessels, leakage is reduced and proper perfusion established in the blood vessels.
