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. 2020 Jun 11;11:862. doi: 10.3389/fphar.2020.00862

Figure 2.

Figure 2

Inhibitory effects of L-PGDS and L-PGDS/drug complex on Aβ(1–40) peptide aggregation. (A) Representative time course of spontaneous Aβ(1–40) peptide aggregation in the absence (black) or presence of L-PGDS in 1:10 (protein:peptide) ratio (red) or presence of L-PGDS/CPM complex in ratio 1:3 (protein:drug) ratio (blue) or resence of L-PGDS/TRD complex in ratio 1:3 (protein:drug) ratio (green). (B) Disaggregation of preformed Aβ(1–40) fibrils by L-PGDS or L-PGDS/CPM complex in 1:3 (protein:drug) ratio and L-PGDS/TRD complex in 1:3 (protein:drug) ratio. Data shown are means ± SEM (n = 6). (C) Representative time course of spontaneous Aβ(1–40) peptide aggregation in the absence of compounds (black) or presence CPM in 1:1 ratio (red) or presence TRD in 1:1 ratio (blue). (D) Number of fibrils for each condition measured from the TEM images.