Figure 6.

Comparison of the age dependency of the body weight normalized clearance (left hand side) and the steady state volume of distribution (right hand side) relative to the adult value for different simulations for palivizumab and bevacizumab (PBPK and published population PK models (Robbie et al., 2012; Han et al., 2016b)) and allometric scaling. The results of the published population PK models for palivizumab are shown up to an age of 2 years. Relative to the adult value, the PBPK simulations for palivizumab and bevacizumab are virtually the same (simulations for palivizumab are shown).