Table 2.

Input PBPK parameters used.

	Palivizumab	Bevacizumab
Drug-specific input parameters
Molecular weight [kDa]	150a)	150a)
Hydrodynamic radius [nm]	5.34b)	5.34b)
Dissociation constant for FcRn binding [µM]	0.863c)	0.884c)
Equilibrium dissociation constant for target binding [nM]	NA	0.058d)
Dissociation rate constant for target binding [s−1]	NA	3.1E-5d)
Physiological input parameters used for the model extension describing TMDD
Target concentration f) [µM]	NA	0.0113c)
Target synthesis rate constant [day−1]	NA	0.401e)
Degradation rate constant (drug-target complex) [day−1]	NA	0.0482c)

^a)(Lobo et al., 2004); ^b)(Taylor and Granger, 1984); ^c)fitted to plasma concentration-time profiles for adults; ^d)(Papadopoulos et al., 2012); ^e)(Panoilia et al., 2015); ^f)target concentration in the organ with the highest concentration (large intestine).