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. 2020 May 19;118(12):3008–3018. doi: 10.1016/j.bpj.2020.05.004

Figure 1.

Figure 1

A survey of experimentally measured protein diffusion coefficients on DNA and MT molecules. The diffusion coefficients, D, of 16 DNA-binding proteins (DBPs; blue circles) and 26 MT-binding proteins (MBPs; red circles) are shown as a function of the reciprocal radius (R) of each protein. The diffusion coefficients of both types of proteins span approximately four orders of magnitude and depend linearly on 1/R, consistently with the Stokes-Einstein diffusion relation (D = KBT/6πηR), as indicated by the dashed black line, which is the best linear fit to all the data points in this figure (slope = 2.4, R = 0.41). The protein radius, R, was estimated from the protein chain length (73) because the three-dimensional structures of many of these proteins have not been resolved. The full data set is summarized in Table S1. To see this figure in color, go online.