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. 2020 May 1;118(12):2938–2951. doi: 10.1016/j.bpj.2020.04.028

Table 1.

The Interaction Force Constants for HENM Effective Harmonic Bonds Formed between Lateral Interacting Tubulin Domains at the Top of the MT PFs

ββ PF1-PF2 αα PF1-PF2 ββ PF2-PF3 αα PF2-PF3
GTP 1.0 2.4 0.7 2.6
GDPPi 1.3 1.4 0.4 1.5
GDP 0.1 1.0 0.4 0.7

Those values were fitted using a simple one-site-per-domain HENM model to reproduce the mean-square distance fluctuations observed in our atomistic simulations. The units of force constants are in kcal/(mol·Å2).