Figure 4.
Cell migration ability under persistent external stimuli. (a) The average speed as a function of different initial line tension is shown. The average speed is determined by the ratio between the distance traveled and the total simulation time. (b) Reduction in the aspect ratio of cells to four representative values of initial line tension is shown. The aspect ratio measures the ratio between the maximum/minimum radius of cells, depending on the time of movement. Dots in green, red, blue, and gray mean the sample points collected via simulations, whereas the corresponding sinusoidal smoothing curves have an average coefficient of determination R2 = 0.8855. (c) Cell migration ability and spatial profile of F-actin in low tension is shown. σ is at the value of 0.005 pN/μm, and the color bar indicates the concentration of F-actin. (d) The cell barely changes shape, with the maximum concentration of F-actin falling significantly, at a high cell tension of 0.02 pN/μm. To see this figure in color, go online.