Skip to main content
. 2020 Jul;72(3):639–667. doi: 10.1124/pr.119.019026

Fig. 4.

Fig. 4.

MiR-223 in inflammatory monocytes dampens intestinal inflammation. DSS-induced intestinal injury leads to the upregulation of MiR-223 in inflammatory monocytes. Increased miR-223 levels result in the inhibition of its target gene NLRP3, and dampened NLRP3 sequesters inflammasome activity and downstream production of inflammatory cytokines, such as IL-1β. Turning down IL-1β attenuates intestinal inflammation and histologic signs of intestinal injury. Pharmacological enhancement of miR-223 could potentially alleviate acute gut injury and intestinal inflammation in the perioperative period (Neudecker et al., 2016, 2017b,c; Yuan et al., 2018a).