Figure 1.

Cartoon representation of the three states of Htt. In the monomer state, the peptide collapses into a globule containing both polyQ and N-terminal regions. The oligomer state is a micelle-like assembly of a few thousand monomers with a spherical core containing the polyQ and N-terminal regions. The fibril state is a cross-β amyloid core of polyQ flanked by disordered tails on both sides. To see this figure in color, go online.