Figure 7.

APG‐1252 enhanced the antitumor effects of chemotherapeutic drugs in vivo. A, The xenograft tumor volumes of the combined group grew more slowly than did tumors in the other groups. B, The tumo volume of the combined group was the smallest. C, Compared to the other groups, the tumor weight in the combination treatment group was lightest. D, No significant differences in body weight were found among the four groups. E, F, In situ TUNEL staining showed the extent of apoptosis in a xenograft tumor model. G, We analyzed the level of BCL‐2, MCL‐1, BAX, Cleaved Caspase 3, and Ki‐67 by the method of immunohistochemistry. H, Quantification of the proliferation index (Ki‐67) in the four groups