Figure 4.

Histograms depicting the incidence of the main severe toxicities over the initial six courses of chronoIFLO, in male or female patients as a function of peak delivery rate of irinotecan occurring in the morning (05:00 or 09:00), in the afternoon (13:00‐17:00), or at night (21:00‐01:00). A, Neutropenia (grades 3‐4); B, Anemia (grades 2‐4); C, Diarrhea (grades 3‐4); D, Anorexia; (grades 3‐4); E and F, Fatigue (grade 3, and grades 2‐3, respectively). The displayed p‐values from Fisher's exact test correspond to the statistical significance of sex*timing interactions from Fisher's exact test for each endpoint