FIGURE 1.

A, A comparison of the cerebrospinal fluid (CSF) concentrations of CXCL13 between CNS lymphomas and other CNS diseases (germ cell tumor, glioblastoma, other glioma, metastatic tumor, other brain tumor, multiple sclerosis, iNPH, and other diseases). The CSF CXCL13 levels of CNS lymphoma were significantly higher than those of the other diseases. (*P < .001). B, ROC curve of CSF CXCL13. AUC is 0.981. C, Immunohistochemistry of CXCL13 in CNS lymphoma specimens and other brain tumor specimens. The CXCL13 expression levels increased in the CNS lymphoma specimens compared with the other tumor specimens. (a‐d) CNS lymphoma, (e‐f) GBM, (g) anaplastic oligodendroglioma, (h) anaplastic astrocytoma, (i‐j) diffuse astrocytoma, (k) ependymoma, and (l) medulloblastoma (original magnification: ×200). D, Immunohistochemistry of CXCR5 in the CNS lymphoma specimens (original magnification: ×200)