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. 2020 Apr 20;9(12):4114–4125. doi: 10.1002/cam4.3048

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© 2020 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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A, Comparison of the serum or cerebrospinal fluid (CSF) levels of CXCL13 between CNS lymphoma and the other CNS diseases. B, Changes in the CSF CXCL13 concentration in the disease process. At recurrence, CSF CXCL13 levels increased again. C, A flow chart of the PCNSL patient selection in the survival analysis. D, Comparison of Kaplan‐Meier PFS (left panel) and OS (right panel) curves according to the concentrations of CSF CXCL13 (high > 1500 pg/mL, low < 1500 pg/mL; p: log‐rank and Wilcoxon analysis)