TABLE 5.
Retained models for each kind of peptide binding
| Dependent variable | ||
|---|---|---|
| Freq | ||
| Terms | Strongest | Weakest |
| LocusB | −0.121*** (0.028) | 0.44*** (0.033) |
| LocusDR | −0.046 (0.028) | −0.068** (0.033) |
| RegionNAF | 0.028 (0.029) | 0.04 (0.035) |
| RegionEUR | 0.109*** (0.022) | 0.037 (0.027) |
| RegionSWA | 0.051* (0.028) | −0.025 (0.033) |
| RegionNEA | 0.045* (0.024) | −0.022 (0.028) |
| RegionSEA | −0.033 (0.023) | −0.023 (0.028) |
| RegionAUS | −0.063** (0.031) | −0.131*** (0.037) |
| RegionOCE | −0.081*** (0.022) | −0.096*** (0.027) |
| RegionNAM | 0.305*** (0.026) | −0.116*** (0.031) |
| RegionSAM | 0.314*** (0.031) | −0.151*** (0.037) |
| LocusB:RegionNAF | −0.075* (0.041) | 0.04 (0.049) |
| LocusDR:RegionNAF | −0.079* (0.041) | −0.121** (0.049) |
| LocusB:RegionEUR | −0.183*** (0.031) | 0.058 (0.038) |
| LocusDR:RegionEUR | −0.115*** (0.031) | −0.123*** (0.038) |
| LocusB:RegionSWA | −0.118*** (0.039) | 0.092* (0.047) |
| LocusDR:RegionSWA | −0.044 (0.039) | −0.058 (0.047) |
| LocusB:RegionNEA | −0.119*** (0.033) | 0.114*** (0.040) |
| LocusDR:RegionNEA | −0.111*** (0.033) | −0.064 (0.040) |
| LocusB:RegionSEA | −0.015 (0.033) | 0.021 (0.040) |
| LocusDR:RegionSEA | −0.096*** (0.033) | −0.063 (0.040) |
| LocusB:RegionAUS | −0.007 (0.043) | 0.232*** (0.052) |
| LocusDR:RegionAUS | −0.076* (0.043) | 0.045 (0.052) |
| LocusB:RegionOCE | 0.057* (0.032) | 0.09** (0.038) |
| LocusDR:RegionOCE | −0.066** (0.032) | 0.01 (0.038) |
| LocusB:RegionNAM | −0.381*** (0.036) | −0.001 (0.044) |
| LocusDR:RegionNAM | −0.436*** (0.036) | 0.031 (0.044) |
| LocusB:RegionSAM | −0.393*** (0.043) | −0.017 (0.052) |
| LocusDR:RegionSAM | −0.459*** (0.043) | 0.07 (0.052) |
| Constant | 0.202*** (0.020) | 0.153*** (0.024) |
| Observations | 372 | 372 |
| R2 | 0.859 | 0.954 |
| Adjusted R2 | 0.847 | 0.95 |
| Residual Std. Error (df = 342) | 0.052 | 0.063 |
| F Statistic (df = 29; 342) | 71.608*** | 244.587*** |
Note: The dependent variable is the frequency (Freq) of the strongest (left) and weakest (right) HLA binders. The left column (terms) lists all the independent variables and their interactions. For each retained model (Strongest and Weakest) the first column displays the coefficients of the model, that is, the differences in average cumulated frequencies between the group defined by each term and the reference (Locus: A; Region: SAF, grouped on the constant term); the second column shows asterisks indicating the significance level of a test for the coefficient being zero (no effect); and the third column presents in parentheses the values of the standard errors associated with the coefficients.
P < .1;
P < .05;
P < .01.