Table 2.
Patient Demographics and Comorbidities by Category of Peak ALT Elevation Among Patients With Positive Test for SARS‐CoV‐2
| Overall (n = 2,273) | ALT <2× ULN (n = 1,784) | ALT 2‐5× ULN (n = 344) | ALT > 5× ULN (n = 145) | P Value | |
|---|---|---|---|---|---|
| Age (years), median (IQR) | 65 (52, 76) | 66 (53, 78) | 61 (50, 73) | 63 (50, 71) | <0.001 |
| Sex (%) | <0.001 | ||||
| Male | 1,297 (57) | 949 (53) | 242 (70) | 106 (73) | |
| Female | 976 (43) | 835 (47) | 102 (30) | 39 (27) | |
| BMI (kg/m2), median (IQR) | |||||
| BMI >35 kg/m2 (%)* | 347 (17) | 263 (17) | 57 (18) | 27 (20) | 0.6 |
| Hispanic/Latino ethnicity (%) | 1,140 (50) | 884 (50) | 184 (53) | 72 (50) | 0.7 |
| Race | |||||
| White | 531 (23) | 426 (24) | 75 (22) | 30 (21) | 0.5 |
| Black | 478 (21) | 387 (22) | 66 (19) | 25 (17) | 0.3 |
| Asian | 20 (0.9) | 15 (0.8) | 2 (0.6) | 3 (2.1) | 0.2 |
| Other/unknown | 1,274 (56) | 984 (55) | 202 (59) | 88 (61) | 0.2 |
| Comorbidities (%) | |||||
| HTN | 1,375 (60) | 1,130 (63) | 166 (48) | 79 (54) | <0.001 |
| Diabetes | 886 (39) | 738 (41) | 100 (29) | 48 (33) | <0.001 |
| Chronic kidney disease | 470 (21) | 346 (19) | 69 (20) | 55 (38) | <0.001 |
| Asthma | 308 (14) | 259 (15) | 34 (9.9) | 15 (10) | 0.036 |
| COPD | 185 (8.1) | 163 (9.1) | 15 (4.4) | 7 (4.8) | 0.004 |
| Pulmonary fibrosis | 17 (0.7) | 15 (0.8) | 1 (0.3) | 1 (0.7) | 0.6 |
| Any pulmonary disease | 430 (19) | 364 (20) | 45 (13) | 21 (15) | 0.002 |
| Chronic liver disease (%) | 114 (5.0) | 91 (5.1) | 15 (4.4) | 8 (5.5) | 0.8 |
| Advanced fibrosis or cirrhosis | 31 (1.4) | 27 (1.5) | 3 (0.9) | 1 (0.7) | 0.7 |
| Alcohol‐related liver disease | 12 (0.5) | 8 (0.4) | 3 (0.9) | 1 (0.7) | 0.4 |
| NAFLD or NASH | 44 (1.9) | 33 (1.8) | 5 (1.5) | 6 (4.1) | 0.14 |
| HBV | 15 (0.7) | 11 (0.6) | 3 (0.9) | 1 (0.7) | 0.6 |
| HCV | 44 (1.9) | 35 (2.0) | 8 (2.3) | 1 (0.7) | 0.5 |
| Autoimmune hepatitis | 2 (<0.1) | 1 (<0.1) | 0 (0) | 1 (0.7) | 0.15 |
| PBC | 2 (<0.1) | 2 (0.1) | 0 (0) | 0 (0) | >0.9 |
| PSC | 5 (0.2) | 5 (0.3) | 0 (0) | 0 (0) | >0.9 |
| Hemochromatosis | 4 (0.2) | 3 (0.2) | 1 (0.3) | 0 (0) | 0.6 |
*
N = 2,026.
Abbreviations: COPD, chronic obstructive pulmonary disease; PBC, primary biliary cholangitis; PSC, primary sclerosing cholangitis.