Table 1.
Demographic, clinical features, and outcomes of patients
| Patient | 1 | 2 | 3 | 4 | 5 | 6 |
|---|---|---|---|---|---|---|
| Age, sex | 62, Female | 54, Male | 61, Male | 60, Male | 56, Male | 62, Female |
| Comorbidities | DM, HTN, HLD, and COPD | DM, HTN, HLD, and CAD | DM, HTN, and CKD | DM | Cerebral palsy | DM, HTN, CKD, and stroke |
| BMI | 37.37 | 47.95 | 39.98 | 39.17 | 25.70 | 38.55 |
| Presenting symptoms | Dyspnea, dry cough, fever, abdominal pain, and nausea | Dyspnea, fever, and dry cough | Altering mental status | Dyspnea, fever, cough, and altering the mental status | Altering mental status and fever | Altering mental status |
| Duration of symptoms | 2 d | 4 d | 2 d | 7 d | N/A | 1 d |
| SpO2 RA | 84% | 85% | 87% | 60% | 89% | 89% |
| Initial labs | WBC 7.2 | WBC 9.23 | WBC 11.43 | WBC 15.86 | WBC 7.87 | WBC 7.93 |
| L 21% | L 12% | L 9.5% | L 19.8% | L 4.8% | L 11.9% | |
| Cr 0.56 | Cr 1.4 (BL 1.1) | Cr 2.33 | Cr 0.98 | Cr 0.84 | Cr 2.3 (BL 1.5) | |
| CRP 8 mg/dL | CRP 9.24 mg/dL | CRP 25.64 mg/dL | CRP 15.27 mg/dL | CRP 0.55 mg/dL | FER 1308 DD 302 ng/mL | |
| FER 791 mg/dL | FER 869 mg/dL | FER 1106 mg/dL | FER 977 mg/dL | IL‐6 10 pg/mL | ||
| DD 506 ng/mL | DD 1025 ng/mL | DD 640 ng/mL | DD 1929 ng/mL | |||
| IL‐6 79 pg/mL | ||||||
| Intubation | D 1 | D 1 | D 2 | D 1 | D 1 | D 3 |
| Last labs | WBC 13.67 | WBC 13.6 | WBC 11.85 | WBC 19.65 | WBC 9.58 | WBC 10.6 |
| L 13.2% | L 8.9% | L 10% | L 7.3% | L 7.3% | L 3.9% | |
| Cr 0.56 | Cr 7.03 | Cr 6.55 | Cr 12.94 | Cr 3.15 | Cr 13.19 | |
| CRP 14 mg/dL | CRP 21.89 mg/dL | CRP 34.42 mg/dL | CRP 6.77 mg/dL | DD 2236 ng/mL | ||
| PEEP/FiO2 | 20/100 | 18/100 | 18/80 | 8/40 | 8/50 | 18/100 |
| TTD, h | 7 | 3 | 4 | 20 | 12 | 45 |
| Peak BT | 109.7°F (D 6) | 109.7°F (D 10) | 107.6°F (D 6) | 107.2°F (D 8) | 109.7°F (D 12) | 107.2°F (D 8) |
| Outcome | Death (D 6) | Death (D 10) | Death (D 6) | Death (D 9) | Death (D 13) | Death (D 10) |
Abbreviations: BL, baseline value; BMI, body mass index; BT, body temperature; CAD, coronary artery disease; CKD, chronic kidney disease; COPD, chronic obstructive pulmonary disease; Cr, Creatinine; CRP, C‐reactive protein; D, day of event; DD, D‐dimer; DM, diabetes mellitus; FER, ferritin; FiO2, fraction of inspired oxygen; HLD, hyperlipidemia; HTN, hypertension; IL‐6, interleukin‐6; L, lymphocytes; NA, not applicable; PEEP, positive end‐expiratory pressure; SpO2 RA, oxygen saturation on room air; TTD, time from first onset of hyperpyrexia to death; WBC, white blood cell.