. 2020 Jun 21;127(11):1374–1380. doi: 10.1111/1471-0528.16339

Table 2.

Clinical and biochemical pre‐eclampsia‐related findings in pregnant women with COVID‐19 before, during and after severe pneumonia

	Variables	Case 1	Case 2	Case 3	Case 4	Case 5	Case 6	Case 7	Case 8
Before severe pneumonia	GA (weeks)	30⁺⁰	22⁺⁶	37⁺⁵	36⁺⁴	32⁺⁰	20⁺³	27⁺⁴	20⁺¹
	SBP (mmHg)	130	120	123	117	104	135	107	116
	DBP (mmHg)	74	72	74	67	71	76	67	63
	MAP (mmHg)	92.7	88.0	90.3	83.7	82.0	95.7	80.3	80.7
	Prot/creat (mg/g)	37	180	—	—	—	—	—	—
	AST (U/l)	17	19	15	20	26	19	23	14
	ALT (U/l)	16	30	13	26	20	12	14	22
	Platelets/µl	158 000	242 000	402 000	210 000	275 000	234 000	319 000	242 000
	LDH (U/l)	—	—	—	—	—	—	—	—
	D‐dimer (mg/ml)	—	—	—	—	—	—	—	—
	Creatinine (mg/dl)	0.63	0.49	—	0.79	0.74	0.36	0.45	0.66
	UtAPI >95th centile	No	No	Yes	No	No	No	No	No
	PE/HELLP diagnostic criteria	No	No	No	No	No	No	No	No
During severe pneumonia	GA (weeks)	30⁺¹	24⁺⁴	37⁺⁶	36⁺⁵	32⁺¹	20⁺⁴	28⁺³	20⁺²
	SBP (mmHg)	145	168	156	155	116	115	140	108
	DBP (mmHg)	90	116	98	108	70	68	105	69
	MAP (mmHg)	108.3	133.3	117.3	123.7	85.3	83.7	116.7	82.0
	Prot/creat (mg/g)	855	622	378	514	396	49	948	130
	AST (U/l)	153	122	104	62	38	52	138	113
	ALT (U/l)	170	136	52	39	38	14	65	230
	Platelets/µl	324 000	160 000	279 000	231 000	336 000	243 000	108 000	505 000
	LDH (U/l)	482	370	672	555	517	176	463	312
	D‐dimer (mg/ml)	457	2129	5065	1800	326	119	514	376
	Creatinine (mg/dl)	0.34	0.42	0.85	0.88	0.42	0.20	0.39	0.26
	Hidralazine	Yes	Yes	Yes	Yes	No	No	No	No
	Labetalol	Yes	Yes	Yes	Yes	No	No	Yes	No
	sFlt‐1/PlGF	9.40	20.24	378.90	49.36	24.78	4.60	7.60	5.19
	UtAPI >95th centile	No	No	Yes	No	No	No	No	No
	PE/HELLP diagnostic criteria	Yes	Yes	Yes	Yes	No	No	Yes	No
After severe pneumonia	GA at delivery (weeks)	30⁺¹	Not delivered	37⁺⁶	36⁺⁶	Not delivered	Not delivered	28⁺³	Not delivered
	Reason for delivery	HELLP	—	SARS	SARS	—	—	SARS	—
	GA (weeks)	—	25.5	—	—	33.2	21.5	—	21.3
	SBP (mmHg)	123	132	142	115	116	108	109	110
	DBP (mmHg)	83	75	93	68	79	62	75	64
	MAP (mmHg)	96.3	94.0	109.3	83.7	91.3	77.3	86.3	79.3
	Prot/creat (mg/g)	210	183	426	83	115	83	189	128
	AST (U/l)	39	32	56	43	58	—	23	61
	ALT (U/l)	45	132	41	29	55	—	29	172
	Platelets/µl	312 000	218 000	232 000	258 000	292 000	169 000	364 000	762 000
	LDH (U/l)	222	277	692	325	211	—	353	192
	D‐dimer (mg/ml)	617	1745	3258	—	454	—	347	470
	Creatinine (mg/dl)	0.25	0.3	0.58	—	0.41	—	0.42	0.65
	UtAPI >95th centile	—	No	—	—	No	No	—	No
	PE/HELLP diagnostic criteria	No	No	Yes	No	No	No	No	No

ALT, alanine amninotransferase; AST, aspartate aminotransferase; DBP, diastolic blood pressure; GA, gestational age; LDH, lactate dehydrogenase; MAP, mean arterial pressure; PE, pre‐eclampsia; PlGF, placental growth factor; prot/creat; urine protein to creatinine ratio; SARS, severe acute respiratory syndrome; sFlt‐1, soluble fms‐like tyrosine kinase‐1; UtAPI, uterine artery pulsatility index.