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. 2019 Oct 8;112(6):628–636. doi: 10.1093/jnci/djz195

Figure 2.

Figure 2.

Odds ratios (OR) of overall, serous/poorly differentiated (PD) and endometrioid/clear cell (CC) OC for an increase from the 10th to the 90th percentile in metabolite levels. Odds ratios greater than one are shown in shades of red, and odds ratios less than 1 are shown in shades of blue. P values of .05 or less are overlaid on the plot. Estimates were adjusted for risk factors (duration of oral contraceptive use [none or <3 months, 3 months to 3 years, 3 years to 5 years, more than 5 years], tubal ligation [yes/no], and parity [no children, one child, two children, three children, or four or more children]) and additionally for matching factors (cohort [NHS, NHSII]; menopausal status and hormone therapy use at blood draw [premenopausal, postmenopausal and hormone therapy use, postmenopausal and no hormone therapy use, and missing/unknown]; menopausal status at diagnosis [premenopausal, postmenopausal, or unknown]; age [±1 year]; date of blood collection [±1 month]; time of day of blood draw [±2 hours];and fasting status [>8 hours or ≤8 hours]) in subtype analyses. CER = ceramide; NHS = Nurses' Health Study; NHSII = Nurses' Health Study II; LPC = lysophosphatidylcholine; OC = ovarian cancer; PC = phosphatidylcholine; SM = sphingomyelin.